The Glycan Screening Facility and its expert staff employ advanced electrospray ionization mass spectrometry (ESI-MS) instrumentation and methods to screen carbohydrate libraries (as well as other classes of compounds) against target proteins to identify novel inhibitors and natural receptors that may be exploited for the development new and effective treatments for a variety of bacterial and viral infections as well as other diseases. Our carbohydrate collection includes over 250 compounds (including ABH and Lewis histogroup antigens, human milk oligosaccharides, gangliosides and plant and bacterial oligosaccharides). The Glycan Screening Facility is dedicated to developing novel ESI-MS methods which allow identification, characterization and quantification protein-carbohydrate interactions in vitro. Researchers may access the Glycan Screening Facility through research collaborations or on a fee-for-service basis.
Dr. John Klassen
Principal Investigator – Alberta Glycomics Centre
Professor of Chemistry – University of Alberta
Dr. Rambod Daneshfar
Dr. Elena Kitova