Carbohydrate Synthesis

The chemical synthesis of glycans is a highly specialized research area, requiring individuals with exceptional expertise. The Centre has one of the highest concentrations of glycan synthesis scientists worldwide. In addition to expertise, the Centre is serving as one of only three beta test sites for novel automated instrumentation for synthesizing glycans.

The Centre has also the infrastructure and expertise to analyze and characterize the structure-function of carbohydrates and provide consulting and troubleshooting. Synthesis scale-up could be provided by Centre’s partners.

Examples of carbohydrate synthesis include:

  • Oligosaccharides
  • Building Blocks
  • Sugar Nucleotides
  • Cyclodextrins
  • Rhamnolipids
  • Sphingolipids
  • Glycopeptides
  • Kdo Glycosides
  • Solid-phase oligosaccharide synthesis
  • Chemoenzymatic Synthesis
  • Solid-Phase Synthesis using your Building Blocks
  • Glycoconjugation Methods
  • Glycoconjugate Synthesis

TL

Dr. Todd Lowary Director and Principal Investigator Alberta Glycomics Centre Professor of Chemistry, University of Alberta

Todd L. Lowary received his B.A. in Chemistry from the University of Montana in 1988 and obtained his Ph.D. in Organic Chemistry under the supervision of Professor Ole Hindsgaul at the University of Alberta in 1993.   He carried out postdoctoral research with Professor David R. Bundle at the University of Alberta (1993-1995), and then with Dr. Morten P. Meldal at the Carlsberg Laboratory in Copenhagen, Denmark (1995-1996).   In 1996, he took a position in The Department of Chemistry at The Ohio State University as an Assistant Professor and in 2002 was promoted to Associate Professor with tenure. In 2003, he returned to the University of Alberta where he is a Professor in the Department of Chemistry and the director of the Alberta Glycomics Centre. His research interests are in the area of carbohydrate chemistry and biochemistry, in particular when related to bacterial glycans.

CCL

Dr. Chang-Chun Ling Principal Investigator Alberta Glycomics Centre Associate Professor of Chemistry, University of Calgary

Dr. Ling obtained his PhD degree from the Université de Paris Sud (1991) under the supervision of Dr. Anthony W. Coleman, Prof. Marcel Miocque. He then spent several years (1991-1996) as a post-doctoral fellow with Dr. Raphael Darcy (University College Dublin, 1991-1992), Dr. Stanislas Czernecki (Université Pierre et Marie Curie, 1992-1993) and Dr. David Bundle (University of Alberta, 1993-1996). After spending another two years at Alberta Research Council, he rejoined the Bundle group as a Senior Research Associate (1998). In 2006, he joined the Department of Chemistry, University of Calgary as an Assistant Professor and promoted to the Associate rank in 2012. Dr. Ling’s group is specialized in oligosaccharide synthesis as well as in cyclodextrin chemistry. Currently, his research is focused on the development of carbohydrate-based vaccines and therapeutics to prevent or treat multi-drug resistant bacterial infection, cancer and autoimmune diseases such as multiple sclerosis. In addition, he group is one of the leading groups working in cyclodextrin chemistry. The research group of Dr. Ling can provide different mono- and multi-functionalized cyclodextrin derivatives, both in small and large scales for use in pharmaceutical, nutraceutical and cosmetic formulations.

For more information on this specific project, please contact Dr. Klay Dyer, AGC Manager at 780-248-1908 or via email at klay@ualberta.ca